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Various organic contaminants (OCs) are present in aquatic environments with the potential to bioaccumulate to higher trophic levels. Because of their mainly piscivorous diet, bald eagles (Haliaeetus leucocephalus) can provide information regarding the bioaccumulation of OCs from ...

Halogenated platinum salts can trigger the development of occupational asthma. Until recently, laboratory research into the development and manifestation of platinum hypersensitivity responses were hindered by the lack of an animal model suitable for assessing the functional con...

Excess nitrogen (N) and phosphorus (P) from human activities have contributed to degradation of coastal waters globally. A growing body of work suggests that hydrologically restoring streams and rivers in agricultural and urban watersheds has potential to increase N and P retenti...

Tetrabromobisphenol A Bis(2,3-dibromopropyl) ether (TBBPA-BDBPE) is a high production volume brominated flame retardant (BFR) used in consumer products, resulting in ubiquitous human exposure. Although the major route of exposure for this chemical is believed to be via ingestion,...

Complete systems for laboratory-based inhalation toxicology studies are typically not commercially available; therefore, inhalation toxicologists utilize custom-made exposure systems. Here we report on the design, construction, testing, operation and maintenance of a newly develo...

Multi-hazard risk assessment has long been centered on small scale needs, whereby a single community or group of communities&rsquo; exposures are assessed to determine potential mitigation strategies. While this approach has advanced the understanding of hazard interactions, it i...

Floodplains perform several important ecosystem services, including storing water during precipitation events and reducing peak flows, thus reducing flooding of downstream communities. Understanding the relationship between flood inundation and floodplains is critical for ecosyst...

In August 2015, the US Environmental Protection Agency (EPA) convened a workshop entitled &ldquo;Advancing non-targeted analyses of xenobiotic chemicals in environmental and biological media.&rdquo; The purpose of the workshop was to bring together the foremost experts in non-tar...

This module promotes student discovery and learning about the interconnectedness of humans and ecosystems. Centered on ecosystem services, these six classroom-ready lessons incorporate use of EnviroAtlas to encourage a systems approach to thinking about the world. This approach p...

The industrial use and widespread application of carbon-based nanomaterials have caused a rapid increase in their production over the last decades. However, toxicity of these materials is not fully known and still being investigated for potential human and ecological health risks...

A representative group of multicyclic aromatic hydrocarbons (MAHC) which can be further classified as bridged-ring (bridged-MAHC) or fused-ring (fused-MAHC) were examined for their ability to interact with the estrogen receptor of rainbow trout (rtER) in a hepatic cytosolic estro...

Wetlands in urban and urbanizing areas are often smaller, more degraded, and subject to more stressors than those in undeveloped locations. Their restored level of functioning may never equal that of a site in an undisturbed landscape. Yet, the social benefits from restoring thes...

Objectives. A wide array of military munition constituents are present in water bodies surrounding historically deposited unexploded ordnance. A common approach for monitoring explosive constituents involves the collection of large quantities of discrete water samples combined wi...

Fecal contamination of recreational waters with cattle manure can pose a risk to public health due to the potential presence of various zoonotic pathogens. Fecal indicator bacteria (FIB) have a long history of use in the assessment of recreational water quality, but FIB quantific...

Bayesian networks provide powerful and flexible modeling platforms for examining uncertainty and making inferences. They are especially useful for developing models that reflect causal issues such as how a stressor might impact an environmental endpoint of concern or how a decisi...

Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. Me...

Presentation comparing health advisories and possible health effects of harmful algal blooms (HABS)

The current paper reflects a summary and proceedings of the SETAC sponsored focused topic meeting on High Throughput Screening and Environmental Risk Assessment (hts.setac.org) that was held 16-18 April, 2018. Over 100 participants from academia, government, industry, and other s...

Heart rate assays in wild-type zebrafish embryos have been limited to analysis of one embryo per video/imaging field. Here we present for the first time a platform for high-throughput derivation of heart rate from multiple zebrafish (Danio rerio) embryos per imaging field, which ...

Host-associated microbiota can biotransform xenobiotics, mediate health effects of chemical exposure, and play important roles in early development. Bisphenol A (BPA) is a widespread environmental chemical that has been associated with adverse endocrine and neurodevelopmental eff...

Hurricane Katrina resulted in damage and destruction to local water supplies in Mississippi and Louisiana affecting millions of people. Immediately following the devastation, a multidisciplinary team of 30 EPA emergency response, research, and water program personnel joined forc...

We showed previously that in utero exposure to the cholesterol-lowering drug simvastatin (SMV) during sex differentiation lowers fetal lipids and testicular testosterone production (T Prod) in Hsd:SD rats. Here, the effects of SMV on fetal lipids and T Prod in Crl:CD(SD) rats wer...

This presentation will discuss an introduction to dose-response to include the four steps within the risk assessment process.

This submission is a slide presentation that has already been formerly cleared and presented at the National ACS spring meeting in Boston, MA 2018 (ORD-025841) and the Ground Water Professionals of North Carolina annual meeting in November 2018 (ORD-029090). Changes have been mad...

Prior to the Exxon Valdez oil spill (EVOS), ecological impacts were generally thought to be short-term and controlled by the mono-aromatic and less persistent components of oil. The long term ecological impacts of EVOS were compared to two other extensively studied and more recen...